Mutations within the ATM gene bring about ataxia–telangiectasia. The ATM gene delivers Recommendations for producing a protein that helps Command mobile division and is particularly involved with DNA fix. This protein plays a very important purpose in the normal development and exercise of various body techniques, such as the anxious technique and immune process. The ATM protein helps cells in recognizing destroyed or broken DNA strands and coordinates DNA mend by activating enzymes that take care of the broken strands.
It is a thermostable ligase identified in a number of thermophilic germs, they need NAD+ to be a cofactor.
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They can be applied with restriction endonuclease enzyme to insert DNA fragments, frequently genes, in the plasmid.
The final phosphodiester linkage among the 5’-phosphate team to the DNA chain synthesized by DNA polymerase III and the 3’-hydroxyl team over the chain produced by DNA polymerase I is catalyzed by DNA ligase.
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